Radiation Therapy for the Treatment of Metastatic Gastrointestinal Cancers

This phase II trial studies how well radiation therapy works for the treatment of gastrointestinal cancer that are spreading to other places in the body (metastatic). Radiation therapy uses high energy x-rays to kill cancer cells and shrink tumors. This trial is being done to determine if giving radiation therapy to patients who are being treated with immunotherapy and whose cancers are progressing (getting worse) can slow or stop the growth of their cancers. It may also help researchers determine if giving radiation therapy to one tumor can stimulate the immune system to attack other tumors i

Trial Details

NCT ID
NCT04221893
Phase
NA
Sponsor
University of California, San Francisco
Status
RECRUITING
Cancer Type
Adenocarcinoma Esophageal Cancer
Interventions
  • Radiation Therapy (RT)
Locations (sample)
  • San Francisco, California, United States|37.77493,-122.41942
  • Walnut Creek, California, United States|37.90631,-122.06496

Key Eligibility Criteria

  • Patients must have a histologically, cytologically, or radiographically confirmed metastatic gastrointestinal (GI) malignancy (esophageal, gastroes…
  • Patients must be receiving immunotherapy (checkpoint inhibitor or CTLA4 inhibitor) with overall response of progressive disease by RECIST criteria.
  • Patients must have at least two metastases which are individually progressing as per RECIST criteria, one of which can be safely unirradiated as ad…
  • Patients must have 1-5 sites of disease meeting standard-of-care indications for palliative radiation therapy as adjudicated by the treating radiat…

For full eligibility, visit ClinicalTrials.gov.

Check If You May Be Eligible

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