Study of De_Intensified Postoperative Radiation Therapy for HPV Associated Oropharyngeal Squamous Cell Carcinoma

This research study is studying lowering the standard dose of radiation and chemotherapy after surgery, to minimize the side effects and improve the quality of life.

Trial Details

NCT ID
NCT03875716
Phase
NA
Sponsor
Dana-Farber Cancer Institute
Status
RECRUITING
Cancer Type
HPV Positive Head and Neck Cancer
Interventions
  • Radiation therapy
Locations (sample)
  • Boston, Massachusetts, United States|42.35843,-71.05977

Key Eligibility Criteria

  • Histologically or cytologically confirmed squamous cell carcinoma of the tonsil or base of tongue (oropharynx) or unknown primary with p16-positive…
  • HPV-associated tumor as defined by: positive p16 immunohistochemistry (\>70%) OR in situ hybridization OR PCR-based methods
  • Eligible for curative-intent surgery with anticipated negative margins
  • Surgery performed at Brigham \& Women's Hospital

For full eligibility, visit ClinicalTrials.gov.

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