Pre-operative SRS or Post-operative SRS in Treating Cancer Patients With Brain Metastases

This phase III trial studies stereotactic radiosurgery (SRS) before surgery to see how well it works compared with SRS after surgery in treating patients with cancer that has spread to the brain (brain metastases). SRS is the delivery of focused, high-dose radiation given in a single session to the tumors, with a minimal dose given to uninvolved areas of the brain.

Trial Details

NCT ID
NCT03741673
Phase
PHASE3
Sponsor
M.D. Anderson Cancer Center
Status
RECRUITING
Cancer Type
Brain Cancer
Locations (sample)
  • Houston, Texas, United States

Key Eligibility Criteria

  • The primary lesion pre-operatively can have a maximum diameter of =\< 4 cm for single fraction and =\< 7 cm for multifraction therapy
  • Patients must be considered candidates for SRS within +/- 30 days of surgical resection as defined by either history and physical (H\&P) or present…
  • Patients must have a Karnofsky performance scores \>= 70 or Eastern Cooperative Oncology Group (ECOG) \>= 2 within 30 days of enrollment
  • Patients must agree to randomization as documented by signing the Institutional Review Board (IRB) approved consent form

For full eligibility, visit ClinicalTrials.gov.

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