Epacadostat (INCB024360) Added to Preoperative Chemoradiation in Patients With Locally Advanced Rectal Cancer

The purpose of this research study is to evaluate epacadostat when given with routine radiation therapy and chemotherapy (capecitabine and oxaliplatin) to treat rectal cancer before routine surgery is performed to remove the tumor.

Trial Details

NCT ID

NCT03516708

Phase

PHASE1 / PHASE2

Sponsor

Washington University School of Medicine

Status

RECRUITING

Cancer Type

Colorectal Cancer

Interventions

Epacadostat
Short-course radiation therapy
CAPOX chemotherapy
FOLFOX chemotherapy

Locations (sample)

Orange, California, United States|33.78779,-117.85311
Boston, Massachusetts, United States|42.35843,-71.05977
Detroit, Michigan, United States|42.33143,-83.04575
St Louis, Missouri, United States|38.62727,-90.19789

Key Eligibility Criteria

Newly diagnosed pathologically-confirmed locally advanced rectal cancer (defined by 8th edition AJCC stage 2 or 3, or stage 1 not eligible for sphi…
At least 18 years of age.
ECOG performance status 0, 1, or 2
Adequate bone marrow and organ function as defined below:

For full eligibility, visit ClinicalTrials.gov.

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