Expanded Natural Killer Cells Following Haploidentical HSCT for AML/MDS

The study examines the application of expanded natural killer cells (NK cells) following haploidentical allogeneic hematopoietic stem cell transplantation (haplo-HSCT) for AML or MDS. Haplo-HSCT is a preferred treatment option for patients with AML or MDS without a HLA-matched donor. With administration of cyclophosphamide post-transplant , the safety of the procedure is similar to a HSCT from a HLA-identical donor. Relapse of AML/MDS represents a serious problem following haplo-HSCT. NK cells are immune cells able to destroy tumor cells. Their potency has been established particularly in the

Trial Details

NCT ID
NCT03300492
Phase
PHASE1 / PHASE2
Sponsor
University Hospital, Basel, Switzerland
Status
RECRUITING
Cancer Type
Leukemia
Interventions
  • NK-DLI
Locations (sample)
  • Basel, Switzerland|47.55839,7.57327

Key Eligibility Criteria

  • \>18 years of age
  • No HLA-matched related or unrelated donor available
  • AML or MDS-EB with indication for a haplo-HSCT according to the guidelines of the University Hospital Basel Stem Cell Transplant Team
  • Judged by the transplant physicians to have adequate organ function and no contraindications to haplo-HSCT

For full eligibility, visit ClinicalTrials.gov.

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