Active Surveillance, Bleomycin, Etoposide, Carboplatin or Cisplatin in Treating Pediatric and Adult Patients With Germ Cell Tumors

This phase III trial studies how well active surveillance help doctors to monitor subjects with low risk germ cell tumors for recurrence after their tumor is removed. When the germ cell tumor has spread outside of the organ in which it developed, it is considered metastatic. Chemotherapy drugs, such as bleomycin, carboplatin, etoposide, and cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. The trial studies whether carboplatin or cisplatin is the preferred chemotherapy to use in

Trial Details

NCT ID
NCT03067181
Phase
PHASE3
Sponsor
Children's Oncology Group
Status
RECRUITING
Cancer Type
Ovarian Cancer
Interventions
  • Best Practice
  • Biopsy Procedure
  • Biospecimen Collection
  • Bleomycin Sulfate
  • Carboplatin
  • Cisplatin
Locations (sample)
  • Birmingham, Alabama, United States|33.52066,-86.80249
  • Anchorage, Alaska, United States|61.21806,-149.90028
  • Anchorage, Alaska, United States|61.21806,-149.90028
  • Kingman, Arizona, United States|35.18944,-114.05301
  • Phoenix, Arizona, United States|33.44838,-112.07404

Key Eligibility Criteria

  • There is no age limit for the low risk stratum (stage I ovarian immature teratoma and stage I non-seminoma or seminoma malignant GCT \[all sites\])
  • Standard risk 1: Patients must be \< 11 years of age at enrollment
  • Standard risk 2: Patients must be \>= 11 and \< 25 years of age at enrollment
  • Patients enrolling on one of the low risk arms must be newly diagnosed with a stage I germ cell tumor; for the standard risk arms, patients must be…

For full eligibility, visit ClinicalTrials.gov.

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