Radiation Dose Optimization in Diffuse Large B- Cell Lymphoma.

The purpose of this study is to compare standard dose radiation of 45 Gray(Gy) in 25 fractions in Non Hodgkin's Lymphoma- Diffuse Large B cell Lymphoma (NHL-DLBCL) to that of 36 Gy in 20 fractions. The role of radiation in NHL-DLBCL has been addressed in large cooperative trials showing improvement in overall survival and progression free survival with combined modality treatment. The doses of radiation used in these trials are heterogeneous ranging from 30-55 Gray(Gy). There is uncertainty about the optimal dose of radiation needed in aggressive lymphomas. A dose response phenomenon is known

Trial Details

NCT ID
NCT02964858
Phase
NA
Sponsor
Tata Memorial Hospital
Status
RECRUITING
Cancer Type
Lymphoma
Interventions
  • Standard Arm
  • Experimental Arm
Locations (sample)
  • Mumbai, Maharashtra, India|19.07283,72.88261

Key Eligibility Criteria

  • Histological Diagnosis of NHL- DLBCL.
  • Eligible for RT after R-CHOP.
  • 18 - 65 years.
  • Stage I-IV.

For full eligibility, visit ClinicalTrials.gov.

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