TAPUR: Testing the Use of Food and Drug Administration (FDA) Approved Drugs That Target a Specific Abnormality in a Tumor Gene in People With Advanced Stage Cancer

The purpose of the study is to learn from the real world practice of prescribing targeted therapies to patients with advanced cancer whose tumor harbors a genomic variant known to be a drug target or to predict sensitivity to a drug. NOTE: Due to character limits, the arms section does NOT include all TAPUR Study relevant biomarkers. For additional information, contact TAPUR@asco.org, or if a patient, your nearest participating TAPUR site (see participating centers). \*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*

Trial Details

NCT ID
NCT02693535
Phase
PHASE2
Sponsor
American Society of Clinical Oncology
Status
RECRUITING
Cancer Type
Multiple Myeloma
Interventions
  • Palbociclib
  • Sunitinib
  • Temsirolimus
  • Trastuzumab and Pertuzumab
  • Vemurafenib and Cobimetinib
  • Regorafenib
Locations (sample)
  • Birmingham, Alabama, United States|33.52066,-86.80249
  • Phoenix, Arizona, United States|33.44838,-112.07404
  • Auburn, California, United States|38.89657,-121.07689
  • San Francisco, California, United States|37.77493,-122.41942
  • Bridgeport, Connecticut, United States|41.17923,-73.18945

Key Eligibility Criteria

  • 12 years of age or older (\*Restrictions apply. Not all therapies are available for patients \<18)
  • Histologically-proven locally advanced or metastatic solid tumor, multiple myeloma or B cell non-Hodgkin lymphoma who is no longer benefiting from …
  • Performance status 0-2 (Per Eastern Cooperative Oncology Group (ECOG) criteria)
  • Patients must have acceptable organ function as defined below. However, as noted above, drug-specific inclusion/exclusion criteria specified in the…

For full eligibility, visit ClinicalTrials.gov.

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