Proton Radiation for Unresectable, Borderline Resectable, or Medically Inoperable Carcinoma of the Pancreas

The prognosis for patients with localized pancreatic adenocarcinoma who are not surgical candidates is poor. Patients characterized as having "borderline resectable" disease treated with preoperative chemo-radiotherapy fair somewhat better - although many of these patients are not converted to resectability. It may be argued that intensification of local and regional therapy might 1.) Increase the share of patients able to undergo curative surgery and 2.) Improve the local disease control interval and extend survival for patients who remain unresectable. Therefore, the purpose of this research

Trial Details

NCT ID
NCT02598349
Phase
PHASE2
Sponsor
Proton Collaborative Group
Status
RECRUITING
Cancer Type
Pancreatic Cancer
Interventions
  • Proton Radiation
  • Capecitabine
  • Surgical resection
Locations (sample)
  • Jacksonville, Florida, United States|30.33218,-81.65565
  • Warrenville, Illinois, United States|41.81781,-88.1734
  • Flint, Michigan, United States|43.01253,-83.68746
  • Fairfax, Virginia, United States|38.84622,-77.30637

Key Eligibility Criteria

  • Biopsy proven unresectable adenocarcinoma of the pancreas.
  • Have either unresectable, borderline resectable or medically inoperable carcinoma of the pancreas, or refusing surgery.
  • A biliary obstruction is able to participate as long as a drainage tube is in place prior to starting treatment with Proton radiation,
  • Participants of child-producing potential must be willing to use contraception while on treatment and for at least 12 months thereafter.

For full eligibility, visit ClinicalTrials.gov.

Check If You May Be Eligible

Trialify translates complex eligibility criteria into plain yes-or-no questions to help you understand if this trial might be right for you.

Find Pancreatic Cancer Trials on Trialify →