Hippocampal-Sparing Prophylactic Cranial Irradiation in Pathologically Nodal Positive Non-Small-Cell Lung Cancer

Background. During the clinical course of patients with locoregionally advanced non-small-cell lung cancer (LA-NSCLC) who have undergone aggressive treatment, brain metastasis (BM) is a frequent seen pattern of disease relapse, which cannot be ignored. It still remains unresolved whether prophylactic cranial irradiation (PCI) via whole brain radiotherapy (WBRT) should be recommended for NSCLC patients with stage III or pathologically nodal positive disease. Actually, PCI would significantly decrease the incidence of BM; however, potential WBRT-related neurocognitive function (NCF) sequelae are

Trial Details

NCT ID
NCT02448992
Phase
PHASE2 / PHASE3
Sponsor
Chang Gung Memorial Hospital
Status
RECRUITING
Cancer Type
Lung Cancer
Interventions
  • hippocampal-sparing WBRT
Locations (sample)
  • Taoyuan, Taiwan|24.99368,121.29696

Key Eligibility Criteria

  • Clinical diagnosis of NSCLC
  • Must be adult patients (≥ 18 years old) who have received definitive surgery and have a permanent pathology of nodal metastasis
  • Platinum-based chemotherapy is mandatory
  • Good performance status better than Eastern Cooperative Group (ECOG) of 2 or a general status of Karnofsky (KPS) \> 70 %

For full eligibility, visit ClinicalTrials.gov.

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