Proton Therapy for Esophageal Cancer

The goal of this phase II study is to investigate the feasibility, toxicity and efficacy of a regimen incorporating a proven systemic regimen, carboplatin /paclitaxel, with conformal proton modality, followed by definitive surgery. In most combined-modality trials to date, chemotherapy regimens have included cisplatin, usually in conjunction with 5-fluorouracil. In designing the regimen, the investigators attempt to improve on the standard cisplatin/5-fluorouracil regimen in several ways. First, full-dose paclitaxel is added to the regimen. This agent has activity against advanced esophageal

Trial Details

NCT ID
NCT01684904
Phase
NA
Sponsor
Loma Linda University
Status
RECRUITING
Cancer Type
Esophageal Cancer
Interventions
  • Proton radiation
Locations (sample)
  • Loma Linda, California, United States|34.04835,-117.26115

Key Eligibility Criteria

  • Pathologically confirmed primary squamous cell or adenocarcinoma of the esophagus that involves the mid, distal or esophagogastric junction. The ca…
  • Endoscopy with biopsy
  • Stage T1N102, T2-3N0-2 according to the American Joint Committee on Cancer (AJCC) 7th edition staging, based upon the following minimum diagnostic …
  • History/physical examination with documentation of patient's weight within 30 days of registration

For full eligibility, visit ClinicalTrials.gov.

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