Intensity Modulated Radiotherapy (IMRT) vs. 3D-conformal Accelerated Partial Breast Irradiation (APBI) for Early Stage Breast Cancer After Lumpectomy

In the setting of radiotherapy as part of breast-conservation therapy for patients with early stage breast cancer, the novel planning and delivery method of intensity modulated radiotherapy is an effective and safe alternative to the commonly-used standard 3D-conformal external beam radiotherapy, spares more normal breast and lung tissue, and may lead to improved clinical outcomes.

Trial Details

NCT ID
NCT01185132
Phase
PHASE3
Sponsor
Rocky Mountain Cancer Centers
Status
RECRUITING
Cancer Type
Lobular Carcinoma Breast Cancer
Interventions
  • accelerated partial breast irradiation - 3D-conformal planning
  • accelerated partial breast irradiation - IMRT planning
Locations (sample)
  • Aurora, Colorado, United States|39.72943,-104.83192
  • Boulder, Colorado, United States|40.01499,-105.27055
  • Lakewood, Colorado, United States|39.70471,-105.08137
  • Littleton, Colorado, United States|39.61332,-105.01665
  • Thornton, Colorado, United States|39.86804,-104.97192

Key Eligibility Criteria

  • Histologically confirmed disease (AJC Classification): Tis, T1, T2 (≤ 3.0 cm), N0, M0.
  • Microscopic multifocal disease is only allowed when the entire span of identified disease measures 3.0 cm or less.
  • Negative surgical margins ( ≥ 0.2 cm) after final surgery.
  • Subjects with infiltrating lobular histologies or high nuclear grade DCIS will be required to have breast MRI scanning as part of the initial stagi…

For full eligibility, visit ClinicalTrials.gov.

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