Active Chemotherapy Clinical Trials

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How It Works

1. Share a Few Details — Enter your cancer type, stage, and location. No personal health information is required or stored.
2. Answer Yes-or-No Questions — We rewrite complex eligibility criteria into plain language. "Not sure" is always a valid answer.
3. Bring Results to Your Doctor — Get a printable summary with the NCT ID, match assessment, and questions to ask your oncologist.

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Chemotherapy Clinical Trials FAQ

What new types of chemotherapy are being tested in clinical trials?

Beyond traditional cytotoxic drugs, modern chemotherapy trials are testing antibody-drug conjugates (ADCs) — targeted 'magic bullets' that carry a chemotherapy payload directly to cancer cells — as well as nanoparticle formulations, liposomal drugs, and combinations with immunotherapy or targeted agents. ADCs like trastuzumab deruxtecan (T-DXd) and sacituzumab govitecan have already transformed several cancer types.

Are chemotherapy trials only for patients whose cancer has spread?

No. There are chemotherapy trials for all disease stages. Neoadjuvant trials test chemotherapy before surgery (to shrink a tumor). Adjuvant trials test it after surgery (to prevent recurrence). First-line trials test it as initial treatment. Second-line and later trials test it in patients whose cancer returned or progressed. Trialify lets you filter by disease stage to find trials that match your situation.

How do I know if a chemotherapy trial is better than standard treatment?

Phase 3 trials directly compare a new chemotherapy regimen against the current standard of care — the only way to rigorously prove a treatment is better. Phase 2 trials test whether a new approach is promising enough to advance to Phase 3. Participating in any phase gives you access to an experienced medical team and close monitoring. Ask the trial team to explain the expected benefits and risks for your specific situation.

Can I continue working while on a chemotherapy clinical trial?

Many patients continue working during chemotherapy trials, especially between treatment cycles. Side effects (fatigue, nausea, immune suppression) vary significantly between regimens and between individuals. The trial team will give you a detailed side effect profile and support you in managing them. Some trials offer flexible scheduling or telehealth visits between treatment days.

Chemotherapy Trials by Cancer Type

• Pancreatic Cancer — Pancreatic cancer trials are at the forefront of KRAS inhibitor research, mRNA vaccines, and combination immunotherapy. Participating in a trial may give access to treatments not yet available to the general public.
• Ovarian Cancer — Ovarian cancer trials are investigating PARP inhibitor combinations, antibody-drug conjugates, folate receptor-targeted therapy, and immunotherapy — with studies available for both platinum-sensitive and resistant disease.
• Breast Cancer — Breast cancer trials are testing innovative therapies for all subtypes — HER2+, triple-negative (TNBC), and hormone receptor-positive. New options are opening every month at cancer centers across the country.
• Lung Cancer — Lung cancer is the leading cause of cancer-related death worldwide. Recruiting clinical trials are testing new immunotherapies, targeted therapies, and combination regimens for NSCLC and SCLC patients.